Table 1.

Relationship between expression levels of CCN genes and clinical features in primary ovarian carcinomas

CCN1
Clinical characteristicsCCN1 negative (n = 22)CCN1 positive (n = 37)P
Age
    Mean ± SD66 ± 13.264 ± 11.10.5656*
    Median, Min-Max66 (45-90)65 (37-82)
Stage
    I-II730.0247
    III-IV1532
    (Missing)(0)(2)
Grade
    1-2390.5027
    31826
    (Missing)(1)(2)
Differentiation
    Well + Mod390.5027
    Poor1826
    (Missing)(1)(2)
Histopathologic type
    Serous papillary9170.7093
    Others1320
CCN2
Clinical characteristicsCCN2 negative (n = 32)CCN2 positive (n = 27)P
Age
    Mean ± SD66 ± 13.363± 9.80.302*
    Median, Min-Max66 (37-90)64 (45-82)
Stage
    I-II910.016
    III-IV2225
    (Missing)(1)(1)
Grade
    1-2480.149
    32519
    (Missing)(3)(0)
Differentiation
    Well + Mod480.149
    Poor2519
    (Missing)(3)(0)
Histopathologic type
    Serous papillary19140.562
    Others1313
CCN4
Clinical characteristicsCCN4 negative (n = 51)CCN4 positive (n = 8)P
Age
    Mean ± SD65 ± 12.061 ± 11.20.3953*
    Median, Min-Max65 (37-90)61 (45-80)
Stage
    I-II820.5939
    III-IV425
    (Missing)(1)(1)
Grade
    1-2930.3483
    3395
    (Missing)(3)(0)
Differentiation
    Well + Mod930.3483
    Poor395
    (Missing)(3)(0)
Histopathologic type
    Serous papillary3030.4458
    Others215
CCN5
Clinical characteristicsCCN5 negative (n = 54)CCN5 positive (n = 5)P
Age
    Mean ± SD64 ± 12.066 ± 11.10.6943 test.
    Median, Min-Max64 (37-90)65 (51-79)
Stage
    I-II911.0000
    III-IV443
    (Missing)(1)(1)
Grade
    1-2930.0604
    3422
    (Missing)(3)(0)
Differentiation
    Well + Mod930.0604
    Poor422
    (Missing)(3)(0)
Histopathologic type
    Serous papillary2330.6458
    Others312
CCN6
Clinical characteristicsCCN6 negative (n = 37)CCN6 positive (n = 22)P
Age
    Mean ± SD64 ± 12.565 ± 10.80.6769*
    Median, Min-Max62, 37-9066, 45-81
Stage
    I-II820.2953
    III-IV2819
    (Missing)(1)(1)
Grade
    1-2660.5084
    32816
    (Missing)(3)(0)
Differentiation
    Well + Mod660.5084
    Poor2816
    (Missing)(3)(0)
Histopathologic type
    Serous papillary19140.4232
    Others188
  • Abbreviations: Min-Max, average from the least (min) to the maximum (max); Well + Mod, well differentiated and moderately differentiated.

  • * t test.

  • Statistically significant.

  • Wilcoxon rank sum test, all other calculations used χ2