Table 2.

Local and systemic toxicity associated with the E75/GM-CSF vaccine

PatientLocal gradeSystemic gradeCompleted seriesDose reduction* (cycle no.)
100.6.110YesNo
100.6.210YesNo
100.6.312NoNo
500.6.111YesNo
500.6.210YesNo
500.6.311YesNo
1000.6.12§0YesYes (3)
1000.6.211YesNo
1000.6.32§0YesYes (6)
500.4.111YesNo
500.4.22§0YesYes (4)
500.4.310YesNo
500.4.42§1YesYes (3)
500.4.511YesNo
500.4.62§0YesYes (4)
500.4.710YesNo
500.4.812YesYes (2)
  • * GM-CSF decreased from 250 to 125 μg, while the peptide dose remained the same.

  • Vaccination number at which point the dose was reduced.

  • Syncope.

  • § Forearm erythema/swelling.

  • Flu-like symptoms.