Table 1.

Features of available tumors and analyses done

TumorTiming of tumor resection relative to treatment with gefitinib/erlotinibHistologyTreated with erlotinib (E), gefitinib (G), or neither (N)Erlotinib/gefitinib sensitive (S), insensitive (I), or not applicable (NA)EGFR activity assayedEGFR sequencingEGFR amplification
1BeforeGlioblastomaESYesWild-typeMarginal gain
2BeforeGlioblastomaGIYesWild-type1+ EGFR
3BeforeAnaplastic astrocytomaGSYesNDND
4BeforeGlioblastomaEIYesWild-type6+ EGFR
5BeforeGlioblastomaEIYesWild-typeMarginal gain
6BeforeAnaplastic astrocytomaESNoExons 18-21 wild-type (other exons failed)Failed
7BeforeAnaplastic astrocytomaESYesWild-typeNone
8BeforeAnaplastic mixed gliomaESYesExon 6, heterozygous C219Y6+ EGFR
9DuringGlioblastomaESYesWild-typeNone
10DuringGlioblastomaGIYesWild-type1+ EGFR
11DuringAnaplastic astrocytomaGSYesNDND
12DuringGlioblastomaEIYesNDND
13DuringGlioblastomaEIYesExon 13, heterozygous R521KMarginal gain
14DuringGlioblastomaEIYesExon 13, heterozygous R521KFailed
15DuringGlioblastomaEIYesExon 13, homozygous R521K1+ EGFR
16DuringGlioblastomaGIYesNDND
17DuringAnaplastic mixed gliomaEIYesWild-typeMarginal gain
18DuringGlioblastomaESYesNDND
19DuringGlioblastomaESYesNDND
20DuringGlioblastomaESYesNDND
213 months laterGlioblastomaEINoExon 17, heterozygous R675QMarginal gain
22NAGlioblastomaNNAYesExon 13, homozygous R521K6+ EGFR
23NAGlioblastomaNNAYesExon 13, heterozygous R521K1+ EGFR
24NAGlioblastomaNNAYesNDND
25NAGlioblastomaNNAYesNDND
26NAAnaplastic mixed gliomaNNAYesNDND
27NAAnaplastic astrocytomaNNAYesNDND
28NAAnaplastic astrocytomaNNAYesNDND
29NAGlioblastomaNNAYesNDND
30NAGlioblastomaNNAYesNDND
31NAGlioblastomaNNAYesNDND
32NAAnaplastic mixed gliomaNNAYesNDND
33NAAnaplastic mixed gliomaNNAYesNDND
  • NOTE: Tumor characteristics, treatment, erlotinib/gefitinib sensitivity, and results. Three sets of paired tumors (1 and 9, 2 and 10, and 3 and 11) were resected from the three patients before and during treatment with erlotinib/gefitinib, respectively.

    Abbreviations: NA, not applicable; ND, not done.