Table 3.

DN-101 pharmacokinetic parameters (mean ± SD)

Dose (μg)Cmax (nmol/L)AUC(0-24) (ng·h/mL)AUC(0-∞) (ng·h/mL)T1/2* (h)
15 (n = 3)1.1 ± 0.29.7 ± 1.312.0 ± 2.65.4 ± 3.9
30 (n = 3)2.2 ± 0.815.6 ± 6.920.5 ± 8.411.0 ± 8.1
45 (n = 6)3.4 ± 0.825.3 ± 7.932.2 ± 10.511.3 ± 2.6
60 (n = 10)5.2 ± 1.642.3 ± 8.052.7 ± 12.07.9 ± 5.8
75 (n = 3)3.8 ± 0.838.4 ± 5.851.3 ± 10.110.8 ± 3.1
90 (n = 3)6.9 ± 1.254.3 ± 13.865.8 ± 21.37.4 ± 1.9
105 (n = 3)8.1 ± 4.964.1 ± 25.980 ± 24.811.6 ± 3.7
135 (n = 3)13.7 ± 5.393.4 ± 46.7118.3 ± 52.114.3 ± 5.1
165 (n = 4)14.9 ± 4.895.9 ± 21.8124.6 ± 21.716.2 ± 5.5
  • * Mean ± pseudo SD.