Table 2.

Relationship between tumor VEGF-C protein expression and clinicopathologic features of PTC

VariablesnMedian25-75 percentileP
Age (y)
    ≤451910.431.12-13.33
    >452011.306.84-21.860.325
Gender
    Male1113.132.16-25.41
    Female2810.011.76-17.350.417
Tumor size (mm)
    ≤40339.821.84-19.65
    >40613.2410.11-27.710.186
pTNM
    I/II2210.311.53-13.24
    III/IV1713.157.10-22.400.193
Multifocality*
    Yes1313.131.53-23.71
    No2610.002.04-19.070.551
Extrathyroidal invasion
    Yes2213.145.35-23.51
    No178.651.83-12.990.119
Lymphovascular permeation
    Yes1321.6513.14-26.39
    No268.141.63-12.500.001§
Lymph node metastasis
    Yes2017.078.11-25.47
    No198.651.05-12.770.004§
Distant metastasis
    Yes134.61
    No3810.311.92-19.070.091
  • * Multifocality is defined as the presence of additional tumor foci noncontiguous to the primary tumors in the resected thyroid specimens.

  • Extrathyroidal invasion as the extension of tumor beyond the thyroid capsule to the perithyroidal tissue.

  • The presence of tumor cells within the vascular or lymphatic endothelium.

  • § P < 0.05.