Table 2.

Population variable estimates for unbound paclitaxel

VariableEstimateRSE (%)
CL (L/h)3014.3
V1 (L)2256.0
V2 (L)34507.8
V3 (L)3036.6
Q2 (L/h)1326.6
Q3 (L/h)1516.5
Residual error (%)21.14.9
IIVCL (CV %)4418*
IIVV1 (CV %)5027*
IIVV2 (CV %)3837*
IIVQ2 (CV %)6519*
IIVQ3 (CV %)3733*
CorrIIV CL-V10.4133*
CorrIIV CL-Q20.7120*
CorrIIV CL-Q30.5533*
CorrIIV V1-Q20.4437*
CorrIIV V1-Q30.3850*
CorrIIV Q2-Q30.8922*
  • Abbreviations: RSE, relative standard error (%); CL, clearance; V, volume of distribution; Q, intercompartmental clearance; IIV, interindividual variability; CV, coefficient of variation; Corr, correlation between individual estimates.

  • * RSE is related to the corresponding variance or covariance term.