Table 4.

Estimated covariate effects (Bi) with 95% CI

GenotypeBi (95% CI)
CYP2C8*2
    Heterozygous0.313* (−0.287, 1.485)
    HomozygousNA
CYP2C8*3
    Heterozygous−0.0320 (−0.215, 0.195)
    Homozygous0.0319 (−0.286, 0.499)
CYP2C8*4
    Heterozygous0.146 (−0.185, 0.615)
    HomozygousNA
CYP3A4*3
    Heterozygous0.054* (−0.484, 1.14)
    HomozygousNA
CYP3A5*3C
    Heterozygous0.0764 (−0.129, 0.326)
    Wild type−0.289* (−0.651, 0.391)
ABCB1 3435C>T
    Heterozygous0.0912 (−0.085, 0.297)
    Homozygous0.103 (−0.108, 0.362)
  • NOTE: Clearance = TVCLWt × (1 + Bi). TVCLWT, the typical value of clearance in wild-type group, was 300, 302, 299, 301, and 282 L/h for genotypes CYP2C8*2, CYP2C8*3, CYP2C8*4, CYP3A4*3, and ABCB1, respectively.

    For CYP3A5*3C, the majority of individuals in the studied population was homozygous for the variant allele. Hence, the covariate effect was considered as an effect of having a functional allele (i.e., related to the typical value of clearance in the homozygous variant group): clearance =300 × (1 + Bi).

    Abbreviation: NA, not available.

  • * Based on one individual.