Table 3.

Cox regression analysis of several variables for OS and PFS

VariableNo. patientsPFS
OS
Hazard ratio (95% CI)PHazard ratio (95% CI)P
FOXP3 expression
    High181.000.0041.000.004
    Low810.41 (0.23-0.76)0.39 (0.20-0.74)
Residual disease
    No tumor left371.000.0031.000.002
    Tumor left620.38 (0.20-0.72)0.34 (0.18-0.66)
Grade
    3401.000.3661.000.719
    1 + 2590.78 (0.45-1.34)1.11 (0.63-1.94)
Performance status
    0681.001.00
    1170.63 (0.29-1.37)0.2450.46 (0.22-0.94)0.033
    >1140.49 (0.19-1.28)0.1450.19 (0.23-1.34)0.552
  • NOTE: High FoxP3 expression as well as residual disease are independent prognostic variables for OS and PFS. FoxP3 expression, tumor grade, residual disease after tumor resection, and performance status were analyzed by Cox proportional hazard model using multivariate analysis.