Table 5.

Effect of AG41631 on survival of AA8, EM9, V3, and irs1SF cell lines following a 16-hour exposure to camptothecin

Cell lineLC50 (nmol/L)
CamptothecinCamptothecin + AG14361
AA825.0 ± 3.512.2 ± 2.4*
EM95.6 ± 1.24.0 ± 1.1
V316.1 ± 4.010.2 ± 3.6
irs1SF2.7 ± 0.71.7 ± 0.4§
1.4 ± 0.4
  • NOTE: Cells were treated with camptothecin ± 0.4 μmol/L AG14361 and survival was determined using a clonogenic assay. Mean ± SE LC50 of at least four independent experiments. Mean ± SE PF50 values calculated using LC50 of individual experiments.

  • * P < 0.01, compared with camptothecin alone, Student's paired t test.

  • Not significantly different from camptothecin alone.

  • P < 0.05, compared with camptothecin alone, Student's paired t test.

  • § AG14361 (15 nmol/L) was used.

  • AG14361 (70 nmol/L) was used.