Table 1.

Expression of different adhesion markers in benign nevi and cutaneous melanomas

VariableNo. cases
P*
Nevi (n = 32)Nodular melanomas (n = 122-133) + superficial spreading melanomas (n = 20)
E-cadherin (membranous)
    Weak23790.030
    Strong870
N-cadherin (cytoplasmic)
    Weak31101<0.0001
    Strong043
N-cadherin (membranous)
    Absent994<0.0001
    Present2250
P-cadherin (cytoplasmic)
    Weak3046<0.0001
    Strong192
P-cadherin (membranous)
    Absent477<0.0001
    Present2761
β-Catenin (membranous)
    Weak055<0.0001
    Strong3193
β-Catenin (nuclear)
    Absent5100<0.0001
    Present2649
Wnt5a (nuclear)
    Weak11790.042
    Strong2063
Wnt5a (cytoplasmic)
    Weak301170.013
    Strong025
Frizzled (nuclear)
    Weak585<0.0001
    Strong2757
Frizzled (cytoplasmic)
    Weak3277<0.0001
    Strong065
  • * Pearson's χ2 test.

  • Below median staining index.

  • Staining index 0-4.