Table 2.

Univariate Cox Analysis of 1-month survival, 12-months survival, and overall survival after diagnosis of AML

Covariate1-month survival
12-months survival
Overall survival
HR (95% CI)PHR (95% CI)PHR (95% CI)P
Age (≤60 vs. >60 y)1.1 (0.4-3.0)0.801.1 (0.6-2.1)0.661.5 (0.9-2.3)0.13
Sex1.1 (0.4-2.9)0.840.7 (0.4-1.4)0.330.8 (0.5-1.2)0.26
Cytogenetics (F vs. I vs. A)0.530.430.10
Cytogenetics (A vs. other)0.9 (0.2-4.3)0.931.6 (0.7-3.4)0.291.7 (0.9-3.3)0.13
AML FAB type [M2, (M3), M4 vs. other]1.4 (0.5-3.7)0.501.1 (0.7-2.1)0.581.1 (0.7-1.8)0.66
AML FAB type (M4, M5 vs. other)1.4 (0.5-3.7)0.511.4 (0.8-2.6)0.291.4 (0.8-2.3)0.22
Fever at day 1 (yes vs. no)2.7 (1.1-7.1)0.0442.3 (1.2-4.2)0.0101.8 (1.1-3.1)0.036
Serum YKL-40*1.7 (1.2-2.4)0.0021.6 (1.2-2.0)0.00021.3 (1.1-1.6)0.003
ESR1.0 (1.0-1.0)0.401.0 (1.0-1.0)0.571.0 (1.0-1.0)0.97
Leukocytes count*1.1 (0.9-1.3)0.281.1 (1.0-1.2)0.0961.1 (1.0-1.2)0.059
Hemoglobin0.5 (0.3-1.1)0.0630.7 (0.5-1.1)0.140.7 (0.5-1.0)0.054
Platelet*0.9 (0.6-1.3)0.711.0 (0.8-1.3)0.991.2 (1.0-1.5)0.062
Serum creatinine1.0 (1.0-1.0)0.981.0 (1.0-1.0)0.131.0 (1.0-1.0)0.40
Serum albumin1.0 (1.0-1.0)0.171.0 (1.0-1.0)0.151.0 (1.0-1.0)0.45
Serum bilirubin (normal vs. high)5.4 (1.7-17)0.0131.9 (0.7-5.4)0.252.2 (1.0-5.2)0.094
Serum alanine aminotransferase*1.5 (1.0-2.2)0.0411.2 (1.0-1.6)0.111.1 (0.9-1.3)0.61
Serum aspartate aminotransferase*1.5 (1.0-2.0)0.0371.3 (1.0-1.6)0.0421.1 (0.9-1.4)0.27
Serum alkaline phosphatase*1.7 (1.1-2.7)0.0261.4 (1.1-1.9)0.0181.3 (1.0-1.7)0.032
Serum lactate dehydrogenase*1.2 (0.9-1.7)0.241.2 (1.0-1.5)0.0391.1 (1.0-1.4)0.17
  • NOTE: Age, sex, cytogenetic prognostic groups [favorable (F), intermediate (I) and adverse (A)], AML FAB types, fever at day 1, and serum bilirubin were treated as categorical variables. Seventeen deaths within the first month, 44 deaths within the first year, and 69 deaths during the follow-up until December 2004 (n = 77).

  • * Leukocyte counts, platelets, serum YKL-40, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase were log-transformed and treated as continuous variables.

  • Hemoglobin, serum albumin, creatinine, and ESR were treated as continuous variables.