Table 1.

Effect of i.p. administration with reveromycin A on multiple-organ metastasis produced by SBC-5 cells in NK cell–depleted SCID mice

TreatmentBone
Liver
Lung
Kidney
IncidenceNo.*IncidenceNo.IncidenceNo.IncidenceNo.
Control10/105 (3-7)10/1050 (19-64)10/1014 (10-20)10/103 (1-5)
Reveromycin A, 2.5 mg/kg8/93 (0-4)9/950 (26-103)9/917 (9-20)9/94 (2-7)
Reveromycin A, 10 mg/kg9/103 (0-3)10/1037 (17-67)10/1011 (9-23)10/102 (1-4)
  • NOTE: SBC-5 cells (1 × 106 per mouse) were injected into the lateral tail vein of the NK cell–depleted SCID mice on day 0. The mice were i.p. administered with PBS or reveromycin A (2.5 or 10 mg/kg daily) from days 7 to 34. The mice were killed on day 35 and the production of metastasis was evaluated.

  • * Median (range).

  • P < 0.01.