Table 2.

Effect of s.c. administration with reveromycin A on multiple organ metastasis produced by SBC-5 cells in NK cell–depleted SCID mice

TreatmentBone
Liver
Lung
Kidney
IncidenceNo.*IncidenceNo.IncidenceNo.IncidenceNo.
Control5/55 (4-7)5/556 (42-60)5/527 (14-36)4/51 (0-2)
Reveromycin A, 1 mg/kg × 2/d5/53 (2-5)5/550 (30-96)5/522 (19-29)5/51 (1-2)
Reveromycin A, 2 mg/kg × 2/d4/53 (0-3)4/544 (0-89)4/527 (0-57)4/51 (0-2)
  • NOTE: SBC-5 cells (1 × 106 per mouse) were injected into the lateral tail vein of the NK cell–depleted SCID mice on day 0. The mice were s.c. administered with PBS or reveromycin A (1 or 2 mg/kg twice a day) from days 7 to 34. The mice were killed on day 35 and the production of metastasis was evaluated.

  • * Median (range).

  • P < 0.01, compared with the control group (Mann-Whitney U test).

  • P < 0.001, compared with the control group (Mann-Whitney U test).