Table 2

The distribution of preneoplastic lesions at baseline bronchosocpic examinations in 52 individuals, tabulated according to factors such as gender, COPD, etc

No. patientsTotal no. lesionsAverage no. lesionsPLGDPHGDPProgression to CIS/SCCP
Gender521340.51.00.23
    Male44 (85%)115 (85%)2.629 (66%)15 (34%)1.012/44 (27%)
    Female8 (15%)19 (15%)2.45 (62%)3 (38%)4/8 (50%)
COPD31 (60%)85 (63%)2.70.420 (65%)1.011 (35%)1.011/31 (35%)0.54
Non-COPD21 (40%)49 (37%)2.314 (67%)7 (33%)5/21 (24%)
Medical history
At risk21 (40%)56 (42%)2.70.9012 (57%)0.219 (43%)0.387/21 (33%)0.77
Previous primaries31 (60%)78 (58%)2.522 (71%)9 (29%)9/31 (29%)
Current smokers (average pack years 47)12 (23%)36 (27%)3.00.378 (67%)1.04 (33%)1.00.30
Ex-smokers+ (average pack-years = 42 )40* (77%)98 (73%)2.526 (65%)14 (35%)14/40 (35%)
Ex-smokers38960.850.740.18
    Stop <5 y20 (53%)57 (59%)2.812 (60%)8 (40%)0.749/20 (45%)
    Stop ;≥5 y18 (47%)39 (41%)2.212 (67%)6 (33%)4/18 (22%)
Pack-years520.160.21160.51
    0-2515* (29%)32 (24%)2.112 (80%)3 (20%)0.216/15 (40%)
    >2637 (71%)102 (76%)2.722 (59%)15 (41%)10/37 (27%)
  • NOTE. LGD cohort of individuals (harboring ≥1 squamous metaplasia, mild, or moderate dysplasia) is compared with HGD cohort of individuals (harboring ≥1 severe dysplasia whether or not accompanied by ≥1 LGD lesion). Progression rate to CIS or SCC and Ps are also shown.

  • * Including two never smokers.