The distribution of preneoplastic lesions at baseline bronchosocpic examinations in 52 individuals, tabulated according to factors such as gender, COPD, etc
| No. patients | Total no. lesions | Average no. lesions | P | LGD | P | HGD | P | Progression to CIS/SCC | P | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gender | 52 | 134 | 0.5 | 1.0 | 0.23 | |||||||||||||||
| Male | 44 (85%) | 115 (85%) | 2.6 | 29 (66%) | 15 (34%) | 1.0 | 12/44 (27%) | |||||||||||||
| Female | 8 (15%) | 19 (15%) | 2.4 | 5 (62%) | 3 (38%) | 4/8 (50%) | ||||||||||||||
| COPD | 31 (60%) | 85 (63%) | 2.7 | 0.4 | 20 (65%) | 1.0 | 11 (35%) | 1.0 | 11/31 (35%) | 0.54 | ||||||||||
| Non-COPD | 21 (40%) | 49 (37%) | 2.3 | 14 (67%) | 7 (33%) | 5/21 (24%) | ||||||||||||||
| Medical history | ||||||||||||||||||||
| At risk | 21 (40%) | 56 (42%) | 2.7 | 0.90 | 12 (57%) | 0.21 | 9 (43%) | 0.38 | 7/21 (33%) | 0.77 | ||||||||||
| Previous primaries | 31 (60%) | 78 (58%) | 2.5 | 22 (71%) | 9 (29%) | 9/31 (29%) | ||||||||||||||
| Current smokers (average pack years 47) | 12 (23%) | 36 (27%) | 3.0 | 0.37 | 8 (67%) | 1.0 | 4 (33%) | 1.0 | 0.30 | |||||||||||
| Ex-smokers+ (average pack-years = 42 ) | 40* (77%) | 98 (73%) | 2.5 | 26 (65%) | 14 (35%) | 14/40 (35%) | ||||||||||||||
| Ex-smokers | 38 | 96 | 0.85 | 0.74 | 0.18 | |||||||||||||||
| Stop <5 y | 20 (53%) | 57 (59%) | 2.8 | 12 (60%) | 8 (40%) | 0.74 | 9/20 (45%) | |||||||||||||
| Stop ;≥5 y | 18 (47%) | 39 (41%) | 2.2 | 12 (67%) | 6 (33%) | 4/18 (22%) | ||||||||||||||
| Pack-years | 52 | 0.16 | 0.21 | 16 | 0.51 | |||||||||||||||
| 0-25 | 15* (29%) | 32 (24%) | 2.1 | 12 (80%) | 3 (20%) | 0.21 | 6/15 (40%) | |||||||||||||
| >26 | 37 (71%) | 102 (76%) | 2.7 | 22 (59%) | 15 (41%) | 10/37 (27%) | ||||||||||||||
NOTE. LGD cohort of individuals (harboring ≥1 squamous metaplasia, mild, or moderate dysplasia) is compared with HGD cohort of individuals (harboring ≥1 severe dysplasia whether or not accompanied by ≥1 LGD lesion). Progression rate to CIS or SCC and Ps are also shown.
↵* Including two never smokers.