Table 2

Age of patients (years) with and without methylation of each of 24 genes in their duodenum

GenePC
CP
UnmethylatedMethylatedUnmethylatedMethylated
Tumor suppressor genes
    STK1163.6 ± 13.56649.3 ± 11.8NA
    VHL64.6 ± 14.15450.2 ± 11.9NA
    hMLH165.6 ± 13.860.9 ± 12.348.4 ± 11.350.2 ± 11.7
    E-cadherin62.3 ± 15.165.0 ± 9.449.9 ± 11.753
    p1663.0 ± 13.763.9 ± 14.550.9 ± 10.448.5 ± 9.2
Cancer methylated genes
    Cyclin G63.5 ± 14.366.3 ± 17.050.3 ± 10.8NA
    HLTF64.3 ± 13.4*79.2 ± 6.1*50.8 ± 10.8NA
    SOCS163.0 ± 14.172.1 ± 13.249.8 ± 11.656
    Cyclin D263.3 ± 13.565.8 ± 15.550.0 ± 11.441.5 ± 21.9
    ST1460.9 ± 14.5*71.8 ± 9.7*48.7 ± 10.564.3 ± 16.6
    MGMT65.0 ± 14.470.3 ± 10.449.1 ± 11.645.5 ± 13.0
    CDH360.7 ± 14.3*70.1 ± 11.3*48.1 ± 11.952.4 ± 11.3
    FOXE163.8 ± 14.264.2 ± 13.752.0 ± 10.631
    LHX162.5 ± 13.5*68.1 ± 12.3*50.6 ± 10.663.0 ± 2.8
    DAPK62.4 ± 12.865.4 ± 14.547.7 ± 12.350.1 ± 11.9
    HPP161.4 ± 12.867.3 ± 12.947.7 ± 11.353.1 ± 12.9
    CLDN562.1 ± 14.665.7 ± 12.350.8 ± 10.650.0 ± 16.7
    UCHL153.5 ± 15.3§67.1 ± 12.2§48.8 ± 11.055.4 ± 10.0
    TJP265.2 ± 14.665.2 ± 13.445.0 ± 7.051.2 ± 11.1
    SRBC68.1 ± 14.865.5 ± 13.438.7 ± 13.652.1 ± 10.3
    PIG1157.9 ± 17.763.9 ± 13.547.4 ± 15.150.8 ± 11.8
    ppENK58.8 ± 14.466.7 ± 13.148.6 ± 10.652.7 ± 11.1
    NPTX263.0 ± 6.163.9 ± 12.747.5 ± 12.152.7 ± 10.9
    CLDN465.3 ± 16.063.3 ± 13.65748.6 ± 12.4
  • Abbreviation: NA, not applicable.

  • * P < 0.005.

  • P < 0.05.

  • P < 0.01.

  • § P < 0.0005.