Table 5

Correlation between age and methylation quantity* in the normal duodenum

GeneDiseaseMethylation (%)Proportion of casesAge, mean ± SD (y)
hMLH1PC094.5% (69/73)64.8 ± 11.4
∼102.7% (2/73)59.0 ± 11.4
≥102.7% (2/73)74.5 ± 10.6
CP0100% (32/32)50.3 ± 12.0
HPP1PC083.1% (59/71)63.8 ± 12.2*
∼1011.3% (8/71)70.0 ± 7.3
≥105.6% (4/71)74.5 ± 10.6
CP0100% (34/34)49.7 ± 11.8
UCHL1PC072.4% (55/76)63.3 ± 11.6
∼1013.2% (10/76)70.9 ± 7.7
≥1014.5% (11/76)71.0 ± 8.8
CP0100% (33/33)49.9 ± 11.8
  • NOTE. Methylation was quantified by COBRA.

  • * P = 0.005.

  • P = 0.006.