Table 1

Irradiation experiments

Time to reach 12 mm (d)Regrowth delay (d)Change (days) between control + RX and thalidomide + RX
Intratumoral treatment just before RX
    Nonirradiated control (n = 7)4.5 ± 0.3
    Control + RX (n = 5)8.8 ± 0.4+4.3 ± 0.5
    Thalidomide + RX (n = 5)8.0 ± 0.5+3.5 ± 0.6−0.8 ± 0.7 NS
RX followed by 2 days of treatment
    Nonirradiated control (n = 7)4.5 ± 0.3
    Control + RX (n = 4)10.1 ± 1.10+5.6 ± 0.9
    Thalidomide + RX (n = 4)9.7 ± 0.5+5.2 ± 0.6−0.4 ± 1.2 NS
Four days treatment followed by RX
    Nonirradiated control (n = 8)5.5 ± 0.5
    Control + RX (n = 4)10.1 ± 0.6+4.6 ± 0.8
    Thalidomide + RX (n = 4)9.1 ± 0.3+3.6 ± 0.7−1.0 ± 0.7 NS
Two days treatment followed by RX
    Nonirradiated control (n = 5)5.2 ± 0.3
    Control + RX (n = 5)10.3 ± 0.6+5.1 ± 0.6
    Thalidomide + RX (n = 5)12.1 ± 0.5+6.9 ± 0.61.8 ± 0.7*
  • NOTE. Data are mean ± SE.

  • Abbreviation: NS, not significant.

  • * P < 0.05.