Table 2

Comparison of therapeutic ratios for 90Y- and 131I-AC8 antibody

Ratio*90Y-AC8131I-AC8
Spleen:liver4.89.1
Marrow:liver2.52.5
Lymph nodes:liver0.72.0
Spleen:lungs7.47.9
Marrow:lungs3.72.2
Lymph nodes:lungs1.11.7
  • * Results represent the average target-to-nontarget organ ratio of radiation after injection of 0.5 mg/kg of antibody labeled with 90Y (n = 12) or 131I (n = 3; ref. 19).