Table 5

Effects of cetuximab + single fraction radiation (8 Gy) and/or cisplatin on mean tumor volume in athymic mice bearing NCI-H520 tumors

TreatmentTumor volume, day 42 (cm3)P
Cet vs. Control3.7 ± 2.4 vs. 2.9 ± 1.20.50
RT vs. Control2.6 ± 1.3 vs. 2.9 ± 1.20.83
Cet vs. RT3.7 ± 2.4 vs. 2.6 ± 1.30.38
Cet + RT vs. Control2.1 ± 0.73 vs. 2.9 ± 1.20.55
Cet + RT vs. Cet2.1 ± 0.73 vs. 3.7 ± 2.40.21
Cet + RT vs. RT2.1 ± 0.73 vs. 2.6 ± 1.30.70
CDDP + RT vs. Control0.65 ± 0.35 vs. 2.9 ± 1.20.07
Cet + RT + CDDP vs. Control1.1 ± 0.55 vs. 2.9 ± 1.20.14
Cet + RT + CDDP vs. Cet + RT1.1 ± 0.55 vs. 2.1 ± 0.730.37
Cet + RT + CDDP vs. CDDP + RT1.1 ± 0.55 vs. 0.65 ± 0.350.73
  • Abbreviations: Cet, cetuximab; RT, radiation; CDDP, cisplatin.