Table 6

Effects of cetuximab + fractionated radiation* and cisplatin on mean tumor volume in athymic mice bearing NCI-H292 tumors

TreatmentTumor volume, day 93 (cm3)P
Cet vs. Control4.2 ± 0.90 vs. 4.4 ± 2.50.80
RT vs. Control2.2 ± 1.8 vs. 4.4 ± 2.50.049
Cet + RT vs. Control1.5 ± 0.84 vs. 4.4 ± 2.50.012
CDDP + RT vs. Control1.8 ± 1.4 vs. 4.4 ± 2.50.024
Cet + RT + CDDP vs. Control1.2 ± 1.3 vs. 4.4 ± 2.50.004
Cet + RT + CDDP vs. Cet + RT1.2 ± 1.3 vs. 1.5 ± 0.840.79
Cet + RT + CDDP vs. CDDP + RT1.2 ± 1.3 vs. 1.8 ± 1.40.54
  • Abbreviations: Cet, cetuximab; RT, radiation; CDDP, cisplatin.

  • * 5 Gy twice a week for 2 weeks.