Table 2

Univariate analysis for OS and PFS for all patients in the cohort

OS
PFS
Prognostic factors at transplantationRR (95% confidence interval)PRR (95% confidence interval)P
ALC-15 ≥ 0.5 × 109 lymphocyte/kg0.459 (0.267-0.710)0.00020.527 (0.355-0.741)0.0001
β-2 Microglobulin ≥ 2.7 mg/L1.482 (1.039-2.085)0.0311.475 (1.093-1.967)0.012
Circulating plasma cells >1%2.601 (1.255-4.501)0.0142.491 (1.351-4.000)0.006
Conditioning regimen: melphalan/total body irradiation versus melphalan alone0.638 (0.407-1.106)0.1020.716 (0.494-1.119)0.132
C-reactive protein ≥ 0.8 mg/L1.375 (0.870-2.030)0.160
Creatinine > 2.0 mg/L1.475 (0.910-2.177)0.107
Interventricular septal thickness ≥ 15 mm1.523 (1.069-2.141)0.0211.424 (1.045-1.908)0.026
LDH > normal1.477 (0.933-2.183)0.0911.526 (1.045-2.127)0.030
No. organs involved > 21.876 (1.289-2.671)0.00151.796 (1.300-2.429)0.0007
No. prior therapies to ASCT ≥ 11.316 (0.984-1.743)0.06
Stem cell mobilization regimen:
G-CSF versus Cytoxan/GM-CSF0.666 (0.456-1.002)0.0510.766 (0.570-1.054)0.100
Troponin T ≥ 0.035*2.278 (1.413-3.593)0.00122.177 (1.492-3.111)0.0001
Urine M protein > 0.25 g/d1.319 (0.907-1.919)0.1461.412 (1.066-1.876)0.016
  • * Only available data in 102 patients.