Table 4

Adverse events in fully supplemented patients receiving pemetrexed and cisplatin

All reported adverse events regardless of causality
Pemetrexed + cisplatin (n = 168)
Cisplatin (n = 163)
All grades (%)Grade 3 (%)Grade 4 (%)All grades (%)Grade 3 (%)Grade 4 (%)
Laboratory
    Hematologic
        Neutropenia58.319.05.416.02.50.6
        Leukopenia55.413.71.819.60.60
        Anemia32.75.40.614.100
        Thrombocytopenia26.84.21.29.800
    Renal
        Creatinine15.50.6012.31.20
        Renal failure2.400.61.200
    Hepatic
        Aspartate aminotransferase (SGOT)8.3008.60.60
Clinical
    Constitutional symptoms
        Fatigue80.416.7073.612.30.6
        Fever17.3008.600
        Other constitutional symptoms10.71.80.68.00.60.6
    Cardiovascular general
        Other cardiovascular general11.301.211.01.80
        Thrombosis/embolism7.14.21.83.72.51.2
    Gastrointestinal
        Nausea83.911.30.678.55.50
        Vomiting57.710.10.651.53.70.6
        Constipation44.02.40.639.30.60
        Anorexia34.52.4025.20.60
        Stomatitis/pharyngitis28.01.81.28.600
        Diarrhea without colostomy26.23.6016.00.60
        Other gastrointestinal19.01.20.616.00.60
        Dehydration7.13.01.21.21.20
        Dysphagia/esophagitis/odynophagia6.01.205.500
    Pulmonary
        Dyspnea65.59.50.662.04.91.8
        Other pulmonary20.22.4019.01.20.6
    Pain
        Chest pain39.97.70.630.14.91.2
        Tumor pain18.53.60.614.73.70.6
    Neurology
        Neuropathy/sensory17.30014.70.60
        Mood alteration/depression13.71.209.20.60
    Infection/febrile neutropenia
        Infection without neutropenia11.31.21.24.300
        Infection with grade 3 or 4 neutropenia6.00.604.300
        Infection/febrile neutropenia-other3.01.201.800
        Febrile neutropenia0.60.600.600
    Immune
        Allergic reaction/hypersensitivity2.4000.600
    Dermatology/skin
        Rash/desquamation22.00.609.200