Table 5

Grade 3/4 adverse events in fully supplemented versus never supplemented patients treated with pemetrexed plus cisplatin

Adverse eventsFully supplemented, % (n = 168)Never supplemented, % (n = 32)
Neutrophils/granulocytes24.437.5
Fatigue17.331.3
Leukocytes15.534.4
Nausea11.931.3
Dyspnea11.312.5
Hypertension11.33.1
Vomiting10.734.4
Chest pain8.36.3
Hemoglobin6.09.4
Thrombosis/embolism6.03.1
Platelets5.49.4
Tumor pain4.86.3
Dehydration4.29.4
Constipation3.63.1
Diarrhea without colostomy3.69.4
Febrile neutropenia0.69.4
Infection with grade3/4 neutropenia0.66.3