Table 6

Most common clinical reasons for dose delay—all cycles

ReasonRandomized and treated patients
Fully supplemented patients
Alimta + cisplatin, n (%)Cisplatin, n (%)Alimta + cisplatin, n (%)Cisplatin, n (%)
Scheduling conflict172 (55.8)131 (76.6)134 (58.0)91 (73.4)
Neutropenia68 (22.1)11 (6.4)50 (21.6)7 (5.6)
Creatinine clearance decreased20 (6.5)12 (7.0)13 (5.6)12 (9.7)
Anemia11 (3.6)1 (0.6)5 (2.2)1 (0.8)
Leukopenia9 (2.9)3 (1.8)8 (3.5)3 (2.4)
Stomatitis3 (1.0)03 (1.3)0
Infection1 (0.3)2 (1.2)1 (0.4)1 (0.8)
Fatigue2 (0.6)01 (0.4)0
Rash2 (0.6)01 (0.4)0
Diarrhea1 (0.3)1 (0.6)01 (0.8)
Dyspnea1 (0.3)1 (0.6)1 (0.4)1 (0.8)
Upper respiratory infection1 (0.3)1 (0.6)1 (0.4)1 (0.8)
Vomiting1 (0.3)1 (0.6)00