Table 4

Serial studies of allelic frequency and distribution of mutations in three patients with biallelic mutations

PatientStatusNo. clones evaluatedNo. clones with
Mutation 1*Mutation 2*Double mutationsWild type
18Diagnosis72302
Relapse115213
93Diagnosis106220
Relapse 1112405
Relapse 2103502
52Diagnosis136601
Relapse112207
  • NOTE. No new mutation was detected at relapse.

  • * Mutation 1 and Mutation 2 stand for leftward and rightward mutation, respectively.