Table 3

Survival of glioblastoma multiforme patients based on EGFR expression category of the tumor

VariableMedian survival (95% CI), y
EGFR negativeEGFRwt positive onlyEGFRvIII positive
Overall survival0.96 (0.81-1.11)0.98 (0.68-1.28)1.07 (0.98-1.16)
Overall survival in patients surviving for 1 year or more2.03 (0.50-3.56)2.02 (1.58-2.46)1.21 (1.06-1.36)
Ependymal involvement
    No1.00 (0.83-1.17)1.63 (1.24-2.02)1.07 (1.02-1.12)
    Yes0.90 (0.72-10.8)0.65 (0.54-0.76)0.95 (0.62-1.28)
KPS score
    >801.27 (0.91-1.63)1.46 (0.85-2.07)1.09 (0.87-1.31)
    ≤800.75 (0.65-0.85)0.56 (0.38-0.74)1.06 (0.88-1.24)
Age (y)
    ≤403.48 (1.92-5.04)2.22 (0.24-4.20)1.82 (1.32-2.32)
    41-641.00(0.77-1.23)1.46 (0.90-2.02)1.07 (0.88-1.26)
    ≥650.66 (0.41-0.90)0.56 (0.24-0.88)1.04 (0.74-1.34)
Necrosis
    No1.31 (1.00-1.62)2.22 (0.00-4.55)1.53 (0.64-2.42)
    Yes0.84 (0.66-1.02)0.79 (0.45-1.13)1.07 (1.01-1.13)
  • Abbreviations: wt, wild type; vIII, vIII mutant.