Table 2

Nonspecific toxicity in mice of HA22 and HA22 (R490A)

Dose (mg/kg)BL22HA22 (death/total)HA22 (R490A)
0.750/100/5
1.01/140/100/15
1.2514/144/105/15
1.509/97/1010/15
1.759/1015/15
  • NOTE. On day 0, female Swiss mice (5-6 weeks, 18-22 g weight) were treated by tail vein single injection with various amounts of immunotoxins in 0.2 mL PBS containing 0.2% human serum albumin. Animal mortality was observed for 2 weeks.