Table 1

Effects of AEE788 on tumor volume and body weight in nude mice bearing human cutaneous SCC xenografts

VariableTreatment group*
Control (n = 10)AEE788 (n = 10)
Tumor volume (mm3)
    Median2,1501,000
    Range1,910-2,339499-1,365
Body weight (g)
    Median21.926.2
    Range21.2-24.421.8-28.9
  • * Colo16 human cutaneous SCC cells (4 × 105) were injected s.c. into the flank of nude mice. Eleven days later, mice were randomized for treatment thrice weekly by oral gavage with either AEE788 (50 mg/kg) or the vehicle for AEE788 (control). All mice were killed on day 21 after the start of treatment.

  • P < 0.01 compared with control (Wilcoxon's rank sum test).

  • P < 0.05 compared with control (Wilcoxon's rank sum test).