Table 1

Clinical characteristics of lung cancer patients

MarylandMayoItalyOverallEGFR status
Mutation (%)Single nucleotide polymorphism (%)
Age26 (11.9%)11 (5.0%)
    <655527890 (41.1%)8 (8.9%)5 (5.6%)
    ≥65723720129 (58.9%)18 (14.0%)6 (4.7%)
    Mean65.264.766.665.567.469.8
Gender
    Male862820134 (61.2%)12 (9.0%)7 (5.2%)
    Female4136885 (38.8%)14 (16.5%)4 (4.7%)
Race
    Caucasian876228177 (80.8%)25 (14.1%)8 (4.5%)
    AA401041 (18.7%)1 (2.4%)3 (7.3%)
    Other0101 (0.5%)00
Smoking
    Nonsmoker1314734 (15.5%)12 (35.3)*1 (2.9%)
    Former smoker42341186 (39.4%)11 (12.6%)5 (5.7%)
    Current smoker72161098 (44.8%)3 (3.1%)5 (5.1%)
Pathology
    Adenocarcinoma726428164 (74.9%)25 (15.2%)10 (6.1%)
    Squamous or other NSCLC550055 (25.1%)1 (1.8%)1 (1.8%)
Family cancer history81/11538/64NA118/179 (66%)10/19 (52.6%)8/11 (72.7%)
Mutation of EGFR8 (6.3%)13 (20.3%)5 (17.9%)26P = 0.011
  • NOTE. Percentages indicate the portion of the indicated change in overall samples.

  • * P < 0.0001.

  • P < 0.01.

  • Distribution of mutation among the three cohorts.