Table 2

Immunoreactivity of P53, P16, Bax, Bcl2, and cyclin D1 in preinvasive bronchial lesion and cancer

HistologyP53+ [% (n)]Loss of P16INK4 [% (n)]Cyclin D1+ [% (n)]BBR <1 [% (n)]
N/H0% (0/21)21% (4/19)9% (2/21)0% (0/21)
SM11% (2/17)53% (8/15)11% (2/17)0% (1/17)
mD44% (8/18)55% (10/18)22% (4/18)0% (0/18)
MD55% (10/18)53% (8/15)31% (5/16)11% (2/18)
SD60% (12/20)57% (11/19)35% (6/17)5% (1/20)
CIS54% (18/33)56% (18/32)33% (11/33)15% (5/33)
Invasive carcinoma48% (13/27)63% (17/27)51% (14/27)24% (6/27)
  • NOTE. n, number of positive or negative cases/total number of evaluated cases.