Table 5

Univariate analysis of overall survival in relation to pathologic characteristics

CharacteristicsChemoradiation followed by surgery
Surgery alone
Patients, n (%)* (n = 193)Hazard ratio (95% confidence interval)PPatients, n (%)* (n = 219)Hazard ratio (95% confidence interval)P
Age193 (100)1.018 (1.00-1.04)0.10219 (100)1.002 (0.99-1.02)0.83
Pathologic tumor-node-metastasis stage
    0 (reference)56 (29)1<0.001<0.001
    I21 (11)1.30 (0.56-3.04)0.5536 (16)1
    II65 (34)2.31 (1.24-4.32)0.0161 (28)2.99 (1.44-6.20)0.003
    III41 (21)4.37 (2.36-8.11)<0.00193 (42)9.19 (4.59-18.42)<0.001
    IV10 (5)4.44 (1.82-10.86)0.00129 (13)10.96 (5.09-23.60)<0.001
Residual carcinoma
    0% (reference)62 (32)1<0.00
    1-10%52 (27)2.10 (1.14-3.90)0.02
    11-50%36 (19)2.26 (1.14-4.46)0.02
    >50%43 (22)4.50 (2.49-8.16)<0.001
Signet-ring cell or mucinous histology in surgery specimen
    No (reference)160 (83)10.02179 (82)10.04
    Yes33 (17)0.45 (0.23-0.90)40 (18)1.45 (1.00-2.12)
Signet-ring cell or mucinous histology in biopsy specimen
    No (reference)161 (83)1
    Yes32 (17)0.53 (0.27-1.03)0.06
  • * Because of rounding, not all percentages total 100.

  • Dashes denote that patients treated with surgery alone had at least stage I disease.