Table 1

Genes highly differentially expressed in LAPC-9 androgen-dependent and androgen-independent tumors

Up-regulated in androgen-independent tumorsDown-regulated in androgen-independent tumors
Cell-cell signaling/signal transduction
WWP1 (19.2), GDF1 (7.9), RGS5 (5.9)APOB (10.9), RGS1*(6.8), RAB32 (5.8)CX3CR1*(9.5), EDNRB (6.3), ANXA1*(4.8)AGTR1 (13.7), MME (5.8)ADRB1 (13.1), FGF12 (5.0)LIM (9.5), ABCA5*(4.7)
Cell adhesion/junction/motility
CDH2 (24.3), ANXA1*(4.8)CSPG2 (11.2)CX3CR1*(9.5)DSC (19.1)PCDH16 (6.8)CLDN8*(6.5)
Structure molecule/cytoskeleton
CAV1 (11.8), BIN3 (5.6)NEFL (9.6), ABLIM1 (5.2)SLIT1 (5.8), SGCD (4.8)ANK3 (9.2), PTPN4 (5.4)CLDN8*(6.5)MME*(5.8)
Immune response
APOE (11.0), HLA-C (5.0)RGS1*(6.8), ANXA1*(4.8)IGLL1 (5.4)ULBP2 (14.7), IL1R1 (10.4)DPP4 (14.2), SEMA3C*(5.4)TRG@(13.3), PLA2G7 (4.9)
Cell proliferation/cell cycle
PTN (23.3), ABCA5*(4.7)DNAJA2 (14.7)SEMA3C*(5.4)
Electron transport
CYP4B1 (8.2)MAOA (8.7)STEAP2 (5.5)CYP1B (4.7)
Other functions
SLC7A5 (15.5), LDHB (10.7), BDNF (8.0), PRESS16 (6.4), GSTM4 (5.4), SOX17 (5.0)GSTM2 (15.1), SERPING1 (10.4), SCUBE2 (7.5), MAN1A1 (6.0), SIAT9 (5.3), CUGBP2 (4.7)RBP5 (13.4), HOOK1 (8.0), COL2A1 (6.8), NRXN1 (5.6), PROX1 (5.0)KLK4 (26.2), PPP3R2 (10.1), NUCB2 (5.6), KLK2 (5.2), TRIM29 (5.1)RTN4R (15.9), CXADR (8.3), TMEPA1 (5.5), CPNE1 (5.2), SLC36A1 (5.0)KLK3 (10.2), LPL (6.2), PTPN4 (5.4), CA1 (5.2)
Genes with unknown function
REG4 (19.5), SFRP1 (9.4), BGN (5.9), SIAH1 (5.1)NSE1 (13.9), SPG2 (8.0), NAALAD2 (5.5)LAMA3 (12.8), MSP (6.2), SATB1 (5.1)SLC15A2 (15.3), BMPR1B (9.3), DNAH11 (6.6), PSK-1 (5.7), MBNL1 (5.4), ATSV (4.7)NEDD4L (10.9), BCMP11 (8.4), CDC6 (6.3), ABCC4 (5.6), ChGn (5.0), MGC4544 (4.7)EPS8L3 (9.7), USP43 (8.0), INPP4B (6.2), PTK2 (5.6), CYP4Z1 (4.9)
Androgen responsive
WWP1 (19.2)KLK4 (26.2), KLK3 (10.2), NUCB2 (5.6), ABCA5 (4.7)NEDD4L (10.9), CDC6 (6.3), TMEPA1 (5.5)IL1R1 (10.4), ABCC4 (5.6), KLK2 (5.2)