Table 4

Characteristics of responders to gefitinib and mutations in the EGFR gene

Case nos.HistologyTissueSex/AgeSmokingExon 18Exon 19Exon 21
1SQCMetastatic brain tumorF/54NeverWild-typeDel (Hm) 2,235-2,249Wild-type
2ADCLung tumorF/48NeverWild-typeDel (Ht) 2,235-2,249Wild-type
3BACLung tumorM/74YesWild-typeDel (Ht) 2,236-2,250Wild-type
4BACLung tumorM/67YesWild-typeDel (Ht) 2,235-2,249Wild-type
5ADCLung tumorM/78NeverWild-typeDel (Ht) 2,236-2,253, substitution of T for C at 2,236Wild-type
6ADCLung tumorF/54NeverWild-typeWild-typeSubstitution of G for T at 2,573 (Ht)
7SQCLung tumorM/80YesWild-typeWild-typeWild-type
8ADCLung tumorM/53YesWild-typeWild-typeWild-type
  • Abbreviations: Hm, homozygous; Ht, heterozygous.