Table 3.

Candidate gene predictors of progression to adenocarcinoma in Barrett's esophagus

GenesSymbol
Down-regulated genes
    18-kDa antrum mucosa proteinAMP18
    ATPase, Ca2+ transporting, ubiquitousATP2A3
    Carbonic anhydrase ICA1
    Deleted in azoospermia 2DAZ2
    Deleted in azoospermia 3DAZ3
    Deleted in azoospermia 4DAZ4
    Fatty acid binding protein 1, liverFABP1
    Hypothetical protein FLJ21458FLJ21458
    Mucin 2, intestinal/trachealMUC2
    Mucin 5, subtype B, tracheobronchialMUC5B
    Mucin and cadherin-likeMUCDHL
    Nudix (nucleoside diphosphate linked moiety X)–type motif 2NUDT2
    Orosomucoid 1ORM1
    Pepsinogen 5, group IPGA5
    Phosphoenolpyruvate carboxykinase 1 (soluble)PCK1
    Plasma glutamate carboxypeptidasePGCP
    Progastricsin (pepsinogen C)PGC
    Protease, serine, 7 (enterokinase)PRSS7
    Secretoglobin, family 2A, member 1SCGB2A1
    Solute carrier family 26, member 3SLC26A3
    Sucrase-isomaltaseSI
    UDP glycosyltransferase 2 family, polypeptide B17UGT2B17
Up-regulated genes
    A disintegrin-like and metalloprotease with thrombospondin type 1 motif, 1ADAMTS1
    Connective tissue growth factorCTGF
    Defensin, β4DEFB4
    Dual specificity phosphatase 6DUSP6
    Early growth response 3EGR3
    Early growth response 4EGR4
    Fibroblast growth factor receptor 2FGFR2
    γ-Aminobutyric acid A receptor, πGABRP
    Heparan sulfate (glucosamine) 3-O-sulfotransferase 1HS3ST1
    Inhibitor of growth family, member 1ING1
    Nuclear receptor subfamily 4, group A, member 3NR4A3
    Phorbol-12-myristate-13-acetate-induced protein 1PMAIP1
    Pleckstrin homology-like domain, family A, member 1PHLDA1
    Protocadherin α12PCDHA12
    Ribosomal protein S6 kinase, 70 kDa, polypeptide 1RPS6KB1
    Solute carrier family 7 (cationic amino acid transporter, y+ system), member 5SLC7A5
    SRY (sex determining region Y)-box 9SOX9
    WEE1 homologue (Schizosaccharomyces pombe)WEE1