Table 1.

Clinical characteristics of the high-grade osteosarcoma patients (total number of patients = 47)

Age at diagnosis (median), y16 (4-77)
Gender
    Female/male22/25
Duration of follow-up (median), mo41 (1-329)
Site of primary disease [n (%)]
    Extremity40 (85)
    Pelvis4 (9)
    Other3 (6)
Histologic subtype [n (%)]
    Osteoblastic17 (36)
    Chondroblastic12 (25)
    Others13 (28)
    Unavailable5 (11)
Metastatic status at diagnosis [n (%)]
    Nonmetastatic33 (70)
    Metastatic14 (30)
Metastatic disease (at any time during the evolution of the disease) [n (%)]
    Absent20 (43)
    Present27 (57)
Site of metastatic disease [n (%)]
    None20 (43)
    Lung10 (21)
    Bone2 (4)
    Lung and bone9 (19)
    Lung and/or bone and others6 (13)
Type of samples (timing in the disease evolution) [n (%)]
    Primary biopsy (diagnosis)16 (34)
    Definitive surgery16 (34)
    First relapse6 (13)
    More than one relapse9 (19)
Chemotherapy response [n (%)]
    Huvos I and II23 (49)
    Huvos III and IV13 (28)
    Unavailable/nonapplicable11 (23)
Survival [n (%)]
    Alive29 (62)
    Dead18 (38)