Table 1.

Effect of VEGFsi on tumor-induced bone lysis

Tumor cell injectedBone tumor incidence*Average lytic level
TC717/10 (70%)1.8
TC/si8/10 (80%)2.5
TC/VEGFsi clone 7-12/7 (29/%)0.3
  • NOTE: TC71, TC/si, or TC/VEGFsi clone7-1 cells were inoculated into tibias of nude mice. Three weeks later, radiograph images were obtained.

  • * Mice with bone tumors/total number of mice (% with tumors).

  • Osteolytic bone lesions were graded from 0 to 4 (with 4 being the most lytic) as defined in Materials and Methods.

  • P < 0.01, compared with either TC71 or TC/si.