Table 1.

Development of endocrine therapy

First publishedAuthorType of therapyReferences
1896BeatsonOophorectomy(1)
1922DeCourmellesOvarian irradiation(9)
1939UlrichAndrogens(10)
1944Haddow et al.Synthetic estrogens(5)
1952DouglasPituitary irradiation(11)
1953Huggins et al.Adrenalectomy(12)
1953Luft et al.Hypophysectomy(3)
1956Taylor et al.Cortical steroids(6)
1971ColeAntiestrogen(14)
1973Schwarzel et al.Aromatase inhibition(22)