Table 1.

Summary of PIK3CA mutations in ovarian and breast cancers

ExonNucleotideCodonDomainOvarian*Breast
9G1624AE542KHelical04
9G1633AE545KHelical14
9A1634GE545GHelical01
9A1634CE545AHelical210
20C3075TT1025TKinase33
20A3127GM1043VKinase10
20A3140TH1047LKinase02
20A3140GH1047RKinase12
20T3147GG1049GKinase10
Total tumors with missense mutations2413
Number of tumors screened19872
Percentage of tumors with missense mutations12%18%
  • * Number of ovarian cancers with the specified mutation.

  • Number of breast cancers with the specified mutation.

  • Synonymous mutation.