Table 1.

Clinical data of HNSCC patients and heparanase expression

Tissue immunohistochemistry (% of tumor cells)*
No.LocationAge (y)Distant metastasisTumor-node-metastasisGradeLocal tumorLymph node metastasesCulture PCRCulture WesternCulture immunohistochemistryXenotransplant immunohistochemistryTherapyDisease-free survival (mo)Overall survival (mo)
1Oropharynx52+T3-N2b-MO2PT: 3030+++NDOp + Rad1219
2Larynx65T3-NO-MO3PT: 30+++NDRad + Op + Ch413
3Oral cavity45T1-N2a-Mx3PT: 0ND+++NDOp + RadNo recurrence of diseaseAlive (87)
4Oral cavity72T3-N2b-Mx4PT: 80ND++++++Op + Rad16
5Oral cavity48+T2-N2b-MO3PT: 0ND+++NDOp + Rad + Ch59
6Maxillary sinus61T4-NO-MO3PT: 0+++NDOp12
7Hypopharynx58+T4-N2b-MO3PT: 7080+++NDOp1212
8Larynx47+T3-N2b-MO2PT: 0ND+++NDOp + Rad1523
9Oral cavity48+T2-N2b-M11PT: 550+++NDOp + Rad + Ch4, 59, 5
10Hypopharynx39T2-NO-MO3PT: 00+++NDOp + Rad3036
11Hypopharynx40T4-N2c-MO3ND5+++NDOp + Rad1833
12Oral cavity69+T2-N2c-MO3PT: 5ND+++NDOp + Rad79
13Oropharynx62+T2-NO-MO3ND15+++NDOp + Rad618
14Larynx69T3-Nx-Mx3PT: 40+++++Op + Rad217
15Oropharynx60+T4-N2c-MO3PT: 4075+++NDOp + Rad5,510
16Oral cavity76T4-N2b-MO2PT: 7075+++NDOp + RadNo recurrence of diseaseAlive (30)
17Carcinoma of unknown primary82T1-N2a-MO410++NDNDOp + RadND24
18Larynx67+T1-N3-MO2PT: <515++(+)+Op + Rad2123
19Oral cavity49T4-Nx-MO3Rel: 15++NDNDOp + Rad + Ch26
20Carcinoma of unknown primary44Tx-N2a-Mx30+++Op + RadNo recurrence of diseaseAlive (23)
21Oropharynx59T4-N2b-MO2NDND++NDNDOp + Rad + Ch1319
22Oral cavity52T4-NO-MO3Rel: 10++NDNDOp + Rad + Ch05
23Oral cavity62T1-N3-MO3ND0++NDNDOp + Rad + Ch2437
24Oropharynx64T2-NO-MO2PT: 5++NDNDOpNo recurrence of diseaseAlive (14)
25Oropharynx59T3-NO-MO3PT: 15++NDNDOp + RadNo recurrence of diseaseAlive (12)
  • NOTE: Tumor cell cultures originated from primary tumors (nos. 2, 4-6, 10-16, 18, 19, and 22-25) or lymph node metastases (nos. 1, 3, 7-9, 17, 20, and 21).

    Abbreviations: ND, not done; PT, primary tumor; Rel, relapsed tumor; Op, operation; Rad, irradiation; Ch, chemotherapy.

  • * Percentage of heparanase-expressing tumor cells among all tumor cells in tumor tissue.

  • Patient was excluded from evaluation of survival times since primary tumor was diagnosed and treated elsewhere.