Table 1.

Genes relatively overexpressed in gemcitabine-sensitive pancreatic cancer cell lines

No.Common nameUnigene IDDescriptionChromosomal locationPt
Genes involved in nucleoside metabolism and transportation
1PAICSHs.444439phosphoribosylaminoimidazole carboxylase4q121.65e-06−9.9914
2CDC42EP1Hs.148101CDC42 effector protein (Rho GTPase binding) 122q13.15.95e-05−6.65
3TNNI3Hs.512709troponin I, cardiac19q13.420.00071−5.8469
4DNM1Hs.436132dynamin 19q34.110.0002−5.778
5EBPHs.196669emopamil binding protein (sterol isomerase)Xp11.230.0006−5.6273
6SMARCA3Hs.3068SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 33q240.00058−5.4641
7P2RX4Hs.321709purinergic receptor P2X, ligand-gated ion channel, 412q24.310.00042−5.3659
8CDAHs.72924cytidine deaminase1p36.120.00092−4.822
Genes involved in signaling pathways for cell cycle regulation, proliferation, or apoptosis.
9IGFBP7Hs.435795insulin-like growth factor binding protein 74q124.00e-08−17.251
10p70S6KHs.86858Ribosomal protein S6 kinase, 70kDa17q11.20.00012−8.0003
11BNIP3Hs.79428Bcl2/adenovirus E1B 19 kDa protein interacting protein10q26.30.00014−7.5318
12PXNHs.446336paxillin12q24.230.00017−6.2075
13CHAF1BHs.75238chromatin assembly factor 1, subunit B (p60)21q22.130.00039−5.3061
14RBMS2Hs.438778RNA binding motif, single stranded interacting protein 212q23.20.00045−5.267
15RGS2Hs.78944regulator of G-protein signaling 2, 24 kDa1q31.20.00048−5.0793
16CREMHs.231975cyclic AMP responsive element modulator10p11.210.00059−4.9462
Unknown and other function
17PCCBHs.63788propionyl CoA carboxylase, β polypeptide3q22.11.83e-05−8.037
18MPDZHs.169378multiple PDZ domain protein9p230.00012−7.0767
19SGCEHs.409798sarcoglycan, epsilon7q21.30.00048−7.0147
20GPSN2Hs.306122glycoprotein, synaptic 24q22.19.46e-05−6.6151
21LMNB1Hs.89497lamin B15q23.17.21e-05−6.4772
22FLJ22582Hs.126783hypothetical protein FLJ2258222q13.10.00019−5.7262
23DHCR7Hs.118067-dehydrocholesterol reductase11q13.10.00039−5.4782
24SERPINF2Hs.159509serine proteinase inhibitor, clade F, member 217p13.30.00079−5.3929
25SLC25A1Hs.111024solute carrier family 25, member 122q110.00069−5.0347
26TCN2Hs.417948transcobalamin II; macrocytic anemia22q12.20.00071−5.0308
27RDXHs.263671radixin11q22.30.00092−4.6462