Table 2.

Genes relatively overexpressed in gemcitabine-resistant pancreatic cancer cell lines

No.Common nameUnigene IDDescriptionChromosomal locationPt
Genes for nucleoside metabolism and transportation
28DYT1Hs.278429Homo sapiens dystonia 1, torsion9q34.115.76e-057.10491
29VIPR1Hs.348500vasoactive intestinal peptide receptor 13p22.10.000146.50633
30ATP11CHs.88252ATPase, Class VI, type 11CXq27.10.000555.55326
31MTSS1Hs.77694metastasis suppressor 18q24.130.000515.52812
32SAFBHs.23978scaffold attachment factor B19p13.20.000685.13198
33RALBP1Hs.75447ralA binding protein 118p11.220.000754.7879
Genes involved in signaling pathways for cell cycle regulation, proliferation, or apoptosis.
34SMAD2Hs.110741SMAD, mothers against DPP homologue 218q21.14.3e-057.82148
35FAKHs.434281focal adhesion kinase8q240.000297.03583
36TRAF6Hs.444172Tumor necrosis factor receptor–associated factor 611p130.00016.71903
37MADDHs.82548MAP-kinase activating death domain11p11.26.30e-056.60535
38PPP3CBHs.187543protein phosphatase 3 catalytic subunit, β isoform10q22.20.000126.10191
39TSC1Hs.69429tuberous sclerosis 19q34.130.000395.92062
40STAT5AHs.437058signal transducer and activator of transcription 5A17q11.20.000155.91317
41SOCS5Hs.169836suppressor of cytokine signaling 52p210.000275.88452
42PHF16Hs.82292PHD finger protein 16Xp11.30.000545.84577
43PIK3C3Hs.418150phosphoinositide-3-kinase, class 318q12.30.000355.73027
44UNC13BHs.155001unc-13 homologue B9p13.30.000235.70029
45MAP3K7Hs.290346MAP kinase kinase 76q150.000455.49991
46LTBP1Hs.241257latent TGF-β binding protein 12p22.30.00085.38788
47ITGA9Hs.222integrin, α 93p22.30.000335.35081
48GNAQHs.469951guanine nucleotide binding protein (G protein), q polypeptide2q21.10.000665.30905
49MYST3Hs.93231MYST histone acetyltransferase (monocytic leukemia) 38p11.210.000445.16659
50SKIPHs.178347skeletal muscle and kidney enriched inositol phosphatase17p13.30.000525.13827
51C5Hs.1281complement component 59q33.20.000924.97948
52PPP1R15AHs.76556protein phosphatase 1, regulatory (inhibitor) subunit 15A19q13.330.000754.81317
Unknown and other function
53LRP3Hs.143641low density lipoprotein receptor-related protein 319q126.02e-0610.2416
54SLC9A3Hs.123044solute carrier family 9 (sodium/hydrogen exchanger), isoform 35p15.330.00026.85467
55HSU79266Hs.23642protein predicted by clone 2362711q13.10.000376.59899
56MCART1Hs.46791mitochondrial carrier triple repeat 19p13.30.000146.03726
57SEMA5AHs.528707sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain, and short cytoplasmic domain (semaphorin) 5A5p15.310.000275.69344
58ELNHs.252418elastin7q11.230.000255.53682
59KIAA0663Hs.17969KIAA0663 gene product1q32.10.00035.45804
60OGTHs.405410O-linked N-acetylglucosamine (GlcNAc) transferaseXq13.10.000355.29243
61KIAA0261Hs.439188KIAA026110q23.20.000415.26712
62UAP1Hs.21293UDP-N-acteylglucosamine pyrophosphorylase 11q24.20.000495.22761
63INPP5EHs.25156inositol polyphosphate-5-phosphatase, 72 kDa9q34.30.000395.22321
64HECAHs.6679headcase homologue (Drosophila)6q24.10.000955.16452
65RPS21Hs.372960ribosomal protein S2120q13.330.000715.03318
66PCSK7Hs.443752proprotein convertase subtilisin/kexin type 711q23.20.00064.94516
67SEC23BHs.173497Sec23 homologue B20p11.230.000634.92033
68MGEA5Hs.5734meningioma expressed antigen 510q24.320.000964.79081
69C6orf93Hs.33944chromosome 6 open reading frame 936q24.20.000954.73743
70HAGHHs.155482hydroxyacylglutathione hydrolase16p13.30.000824.72254
71LAMP2Hs.232432lysosomal-associated membrane protein 2Xq240.000864.69221