Table 1.

Expression of mGluR4 in normal and malignant tissues

Malignancy (expression rate)
OrganNormal tissueNo. positive cases/no. cases tested
Salivary gland+/−*0/14 (0%)
    Adenoid cystic carcinoma0/3
    Acinic cell carcinoma0/3
    Mucoepidermoid carcinoma0/2
    Carcinoma ex pleomorphic adenoma0/5
    Epithelial myoepithelial carcinoma0/1
Oral cavity and nasopharynx+1/8 (13%)
    Squamous cell carcinoma0/7
    Undifferentiated carcinoma1/1
Larynx+7/14 (50%)
    Squamous cell carcinoma7/14
Lung+/−5/31 (16%)
    Squamous cell carcinoma3/19
    Adenocarcinoma1/10
    Large cell carcinoma1/2
Esophagus+0/3 (0%)
    Squamous cell carcinoma0/3
Stomach+10/30 (33%)
    Adenocarcinoma10/30
Colon and rectum++17/25 (68%)
    Adenocarcinoma17/25
Liver5/16 (31%)
    Hepatocellular carcinoma3/13
    Cholangiocarcinoma2/3
Gall bladder+1/6 (17%)
    Adenocarcinoma1/6
Pancreas+1/5 (20%)
    Adenocarcinoma1/5
Breast+6/13 (46%)
    Invasive ductal carcinoma4/8
    Invasive lobular carcinoma1/4
    Medullary carcinoma1/1
Uterine cervix+4/25 (16%)
    Squamous cell carcinoma2/21
    Adenocarcinoma2/4
Endometrium+/−0/12 (0%)
    Adenocarcinoma0/12
Ovary3/31 (10%)
    Serous cystadenocarcinoma0/12
    Mucinous cystadenocarcinoma1/2
    Endometrioid adenocarcinoma0/5
    Clear cell adenocarcinoma0/3
    Undifferentiated carcinoma2/4
    Dysgerminoma0/4
    Yolk sac tumor0/1
Testis0/12 (0%)
    Seminoma0/12
Prostate0/4 (0%)
    Adenocarcinoma0/4
Kidney+/−§1/13 (8%)
    Renal cell carcinoma1/11
    Transitional cell carcinoma0/2
Urinary bladder++3/15 (20%)
    Transitional cell carcinoma3/15
Thyroid2/15 (13%)
    Papillary carcinoma1/12
    Follicular carcinoma0/2
    Medullary carcinoma1/1
Adrenal gland+1/12 (8%)
    Adrenal cortical carcinoma1/12
Skin+5/8 (63%)
    Malignant melanoma5/8
  • * Focal expression of mGluR4 in duct of salivary gland.

  • Focal expression of mGluR4 in bronchus and no expression in alveoli.

  • Weak expression of mGluR4 in endometrial gland.

  • § Focal expression of mGluR4 in collecting duct.