Table 3.

Multivariate analysis for disease-free survival

Multivariate analysis
ParametersCase no.DFS (mean, mo)Univariate analysis (P)Hazard ratio (95% CI)P
Age (y)NSNS
    ≤5910654
    >5911254
SexNSNS
    Female8155
    Male13751
Size (cm)NSNS
    ≤3.33452
    >3.318453
SiteNSNS
    Proximal4855
    Distal17052
HistologyNSNS
    Well3255
    Moderate/poor18652
T stageNSNS
    T1/T23860
    T3/T418051
N stage<0.0001NS
    N013060
    N1/N28842
M stage0.0001NS
    M019455
    M12434
Stage<0.00012.6472 (1.6363-4.2826)0.0001
    Stage I + II12261
    Stage III + IV9642
Lymphatic invasion0.0116NS
    Absent16455
    Present5444
Venous invasion0.01682.5837 (1.1758-5.6778)0.0181
    Absent20854
    Present1034
MGluR4 IHC*0.00562.6188 (1.1910-5.7582)0.0166
    −/+19653
    ++930
p53 IHCNSNS
    −8754
    +12852
MSI0.0434NS
    Absent18952
    Present2262
  • Abbreviations: DFS, disease-free survival; MSI, microsatellite instability; 95% CI, 95% confidence interval; NS, statistically not significant; IHC, immunohistochemistry.

  • * No staining of mGluR4 in 11 cases.

  • No staining results in three cases.

  • No microsatellite instability results in seven cases.