Table 2.

Dose levels

Dose levelDose (mg/m2)Number treatedDLT
1108Pericardial effusion
2203
3303
4403
5556Grade 3 GGT
6753
797.53
81273
92203
10295 (MTD)8*
113952Grade 3 pancreatitis and fatigue
  • Abbreviations: MTD, maximal tolerated dose; DLT, dose limiting toxicity; GGT, γ glutaryl transpeptidase.

  • * One patient did not receive any drug.