Table 3.

Drug-related toxicity

ToxicityGrade 1Grade 2Grade 3Grade 4
Hematologic
    Anemia3 (6.8%)6(13.6%)1 (2.3%)0
    Platelets4 (9.1%)1(2.3%)1 (2.3%)0
    Leukopenia2 (4.6%)1 (2.3%)00
Liver
    AP001 (2.3%)0
    Bilirubin (total)001 (2.3%)0
    AST4 (9.1%)01 (2.3%)0
    GGT2 (4.6%)1(2.3%)2 (4.6%)0
    ALT0001 (2.3%)
Other
    Anorexia11 (25%)1 (2.3%)00
    Fatigue15 (34.1%)4 (9.1%)1 (2.3%)0
    Diarrhea11 (25%)1 (2.3%)00
    Nausea8 (18.1%)1 (2.3%)1 (2.3%)0
    Vomiting7 (15.9%)000
    Stomatitis4 (9.1%)000
    Pericardial effusion001 (2.3%)0
    Pancreatitis001 (2.3%)0
  • NOTE: Selected toxicities; worst grade per patient.

    Abbreviations: ALT, alanine aminotransferase; AP, alkaline phosphatase; AST, aspartate aminotransferase; GGT, γ glutamyl transpeptidase.