Table 1.

In vivo pharmacokinetic tissue distribution for liposomal-C6 in a BALB/c mouse 410.4 mammary adenocarcinoma solid tumor model

ng C6/mg tissue
Time (h)BloodTumorSpleenKidneyLiverHeart
0.0166735.67 ± 1.305.94 ± 0.4631.93 ± 2.2073.86 ± 3.98116.27 ± 20.8488.05 ± 3.63
0.166717.60 ± 1.949.21 ± 0.5231.70 ± 2.68167.11 ± 24.9950.81 ± 17.8667.24 ± 9.32
0.514.46 ± 3.878.12 ± 1.5123.15 ± 6.17104.91 ± 29.9925.56 ± 6.9034.49 ± 12.77
112.77 ± 2.127.27 ± 0.3614.99 ± 3.3848.08 ± 2.2912.99 ± 2.3621.79 ± 1.66
47.53 ± 0.128.42 ± 0.408.10 ± 1.1117.66 ± 1.266.93 ± 0.4810.83 ± 0.64
244.30 ± 0.335.65 ± 0.145.17 ± 0.547.95 ± 1.615.95 ± 0.546.70 ± 1.30