Table 3.

Significance of achieving molecular response in sustaining a complete cytogenetic remission

Best Bcr-Abl/Abl ratioNo. evaluableNo. who lost complete cytogenetic remission to
PMedian follow-up from molecular response (range)
PR/Minor/>90%Total (%)
≥0.05%6812 + 4*/5+1*/325 (37)<0.000111.2 (3.0-28.9)
<0.05%1666 + 2*/0/19 (5)18.4 (3-33.4)
>0 and <0.05%745/0/05 (7)0.4815.0 (3.4-30.6)
Undetectable821 + 1*/0/13 (4)14.3 (3-27)
  • * Patients lost complete cytogenetic remission only transiently.