Table 3.

Univariate analysis of clinicopathologic factors for overall and disease-free survival in 93 patients with STS

FactorsCategoryTotal no. patientsOverall survival
Disease-free survival
No. deaths (5-y overall survival rate)PNo. recurrences (5-y disease-free survival rate)P
Histologic classification1: Liposarcoma266 (82.6%)N.S.16 (41.7%)N.S.
2: Malignant fibrous histiocytoma283 (88.0%)16 (54.6%)
3: Leiomyosarcoma156 (56.9%)10 (37.0%)
4: Malignant neurogenic tumor72 (85.7%)6 (28.6%)
5: Synovial sarcoma103 (80.0%)7 (37.5%)
6: Rhabdomyosarcoma32 (0%)2 (0%)
7: Malignant vascular tumor10 (100%)0 (100%)
8: Extraskeletal chondrosarcoma20 (100%)1 (50.0%)
9: Extraskeletal osteosarcoma10 (100%)1 (0%)
Mitotic count1: ≤5/10 HPF507 (87.0%)<0.0129 (48.5%)N.S.
2: 5-10/10 HPF2311 (61.8%)(1 vs 2 and 3)19 (20.9%)
3: >10/10 HPF204 (78.2%)11 (43.5%)
Cellularity1: Low202 (88.2%)<0.0513 (46.8%)N.S.
2: Moderate398 (84.0%)(1 and 2 vs 3)23 (47.7%)
3: High3412 (68.6%)23 (26.1%)
Cellular pleomorphism1: Minimal418 (84.6%)N.S.27 (42.6%)N.S.
2: Moderate277 (77.3%)17 (38.6%)
3: Marked257 (72.7%)15 (37.6%)
Necrosis1: Absent to minimal6412 (83.4%)<0.0543 (38.2%)N.S.
2: Moderate145 (68.8%)(1 vs 2 and 3)9 (35.7%)
3: Marked155 (73.3%)7 (59.2%)
Sclerosis1: Absent to minimal7216 (81.9%)N.S.47 (38.6%)N.S.
2: Moderate134 (69.2%)6 (61.5%)
3: Marked82 (75.0%)6 (37.5%)
Myxoid change1: Absent to minimal5515 (74.9%)N.S.38 (36.4%)N.S.
2: Moderate185 (80.8%)8 (52.1%)
3: Marked202 (89.7%)13 (44.4%)
Ki-67 LI1: <20%527 (87.2%)N.S.33 (42.5%)N.S.
2: ≥20%4115 (69.0%)26 (38.9%)
Age (y)1: ≤605413 (77.4%)N.S.34 (39.4%)N.S.
2: >60399 (81.4%)25 (42.0%)
Gender1: Male5312 (82.4%)N.S.33 (38.5%)N.S.
2: Female4010 (74.8%)26 (43.8%)
Tumor location1: Upper extremity226 (72.4%)N.S.13 (32.9%)N.S.
2: Trunk215 (85.7%)15 (41.7%)
3: Lower extremity5011 (79.2%)31 (43.3%)
Tumor size1: ≤5 cm303 (96.7%)<0.0520 (42.0%)N.S.
2: 5-10 cm287 (74.3%)(1 vs 2 and 3)17 (42.4%)
3: >10 cm259 (65.7%)(1 and 2 vs 3)14 (41.9%)
Tumor depth1: Superficial112 (100%)N.S.6 (54.6%)N.S.
2: Deep7417 (78.3%)47 (38.9%)
Types of surgery1: Intralesional excision22 (0%)N.S.2 (0%)<0.0001
2: Marginal excision345 (93.7%)31 (21.7%)(1, 2, and 4 vs 3)
3: Wide excision5515 (72.5%)24 (55.6%)
4: Amputation20 (100%)2 (0%)
Adjuvant chemotherapy1: Done4715 (68.4%)<0.0525 (43.3%)N.S.
2: Not done467 (90.1%)33 (38.0%)
Adjuvant radiotherapy1: Done185 (76.9%)N.S.11 (41.7%)N.S.
2: Not done7517 (79.8%)48 (39.9%)
p-AKT expression1: Level 16712 (85.6%)<0.0536 (50.4%)<0.0001
2: Level 22610 (63.2%)23 (13.4%)
p-ERK1/2 expression1: Level 18718 (82.9%)<0.0153 (43.8%)<0.05
2: Level 264 (33.3%)6 (0%)