Table 1.

Amino acid sequence of anti-tenascin-C antibodies at relevant positions

AntigenCloneVH chain
VL chain
31-3452-5695-9831a-3250-5392-95b
TnC-A1D5SYAASGSGGSAHNASYYGKNNVYTMPP
F16RYGASGSGGSAHNASYYGKNNVYTMPP
TnC-DF4SYAMSGSGGSGRRISYYGKNNSPKPKP
D11SYAMSGSGGSGRRIRQPYKKLSPKPKP
P12QYSMTGTGGEGRRIRQPYKKLSPKPKP
  • NOTE: Sequences are given in single-letter amino acid code. Italicized residues in the CDR3 of VH and VL have been mutated in the ETH-2 library; residues in boldface have been mutated for affinity maturation. Numbering is according to Chothia (48, 49).