Table 1.

Associations of CCNE1 and CCNE2 mRNA levels with clinicopathologic factors

CharacteristicNo. patients (%)Median mRNA levels (and interquartile range)*
CCNE1 (×10−1)CCNE2 (×100)
All patients635 (100)0.40 (0.67)0.71 (0.82)
Age (y)
    ≤4086 (14)0.53 (0.59)1.03 (1.15)
    41-55224 (35)0.52 (0.87)0.75 (0.87)
    56-70200 (31)0.38 (0.56)0.70 (0.70)
    >70125 (20)0.28 (0.36)0.56 (0.71)
    P<0.001<0.001
Menopausal status
    Premenopausal265 (42)0.50 (0.76)0.81 (1.06)
    Postmenopausal370 (58)0.34 (0.57)0.67 (0.71)
    P<0.0010.029
Type of surgery
    Breast conserving340 (54)0.42 (0.70)0.76 (0.84)
    Mastectomy295 (46)0.35 (0.62)0.68 (0.83)
    P0.2340.199
Pathologic tumor size (cm)
    ≤2260 (41)0.34 (0.64)0.65 (0.82)
    >2375 (59)0.43 (0.68)0.74 (0.82)
    P0.0150.204
Grade
    Poor331 (52)0.47 (0.80)0.80 (0.95)
    Unknown195 (31)0.35 (0.53)0.70 (0.78)
    Moderate and good109 (17)0.25 (0.52)0.56 (0.66)
    P<0.001§0.009§
ER status
    Negative, <10 fmol/mg protein180 (28)0.93 (1.28)0.77 (0.96)
    Positive, ≥10 fmol/mg protein455 (72)0.29 (0.40)0.70 (0.82)
    P<0.0010.013
PR status
    Negative, <10 fmol/mg protein223 (35)0.74 (1.03)0.81 (1.09)
    Positive, ≥ 10 fmol/mg protein381 (60)0.29 (0.41)0.67 (0.79)
    P<0.001<0.001
Histologic type
    DCIS + ILC81 (13)0.40 (0.59)0.73 (0.66)
    IDC327 (51)0.41 (0.69)0.73 (0.91)
    ILC34 (5)0.25 (0.37)0.61 (0.80)
    Medullary25 (4)0.17 (0.20)0.32 (0.26)
    Mucinous17 (3)1.08 (2.22)0.80 (1.22)
    Others18 (3)0.27 (0.42)0.51 (0.48)
    Unknown133 (21)0.44 (0.81)0.80 (0.80)
    P<0.001§0.001§
  • Abbreviations: DCIS, ductal carcinoma in situ; ILC, infiltrating lobular carcinoma; IDC, infiltrating ductal carcinoma.

  • * Due to different assay conditions, absolute values of the CCNEs can only be compared within a gene assay.

  • P for Spearman rank correlation test.

  • P for Mann-Whitney U test.

  • § P for Kruskal-Wallis test.

  • Due to 31 missing values, numbers do not add up to 635.